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| 1950 |
| | | The Canadian schooner St Roch becomes the first ship to travel through the Panama Canal and the Northwest Passage, thus circumnavigating North America | |
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| 1950 |
| | | The Chilean poet Pablo Neruda publishes his epic account of South America and its people, Canto general | |
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| 1951 |
| | | Jacopo Arbenz, newly elected president of Guatemala, enrages the USA by expropriating the land of the United Fruit Company | |
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| 1951 |
| | | Syntex, a small chemical company in Mexico City, develops the first oral contraceptive | |
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| 1951 |
| | | The Batllistas, followers in Uruguay of José Batlle, attempt an unusual experiment in the reform of government | |
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| 1951 |
| | | Argentinian driver Juan Manuel Fangio wins the first of five Grand Prix world championship titles | |
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| 1952 |
| | | A left-wing coup brings Paz Estenssoro to power and launches a 12-year revolution in Bolivia | |
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| 1952 |
| | | Eva Perón dies of cancer and achieves the status of a popular saint in Argentina | |
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| 1954 |
| | | Alfredo Stroessner seizes power in Paraguay, introducing three decades of repressive dictatorship | |
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| 1954 |
| | | An invasion of Guatemala from Honduras, with CIA support, brings to power a right-wing military junta | |
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